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Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo
TP53 mutations are found in 50% of all cancers and mutated TP53 status is considered poor for treatment. However, some TP53 mutations exhibit only partial loss-of-function (LOF), meaning they retain residual transcriptional and non-transcriptional activities that are potentially beneficial for thera...
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| Wydane w: | Cell Cycle |
|---|---|
| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Taylor & Francis
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6927723/ https://ncbi.nlm.nih.gov/pubmed/31749402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2019.1693748 |
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