Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMA

P53 is a critical tumor suppressor gene, activating p53 and its downstream targets to induce apoptosis is a promising way for cancer therapy. However, more than 50% of cancer patients have p53 mutations, which may cause cancer therapy resistance, and the underline mechanism is poorly understood. Her...

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Vydáno v:Cell Cycle
Hlavní autoři: Huang, Yuan, Liu, Nannan, Liu, Jing, Liu, Yeying, Zhang, Chuchu, Long, Shuaiyu, Luo, Guang, Zhang, Lingling, Zhang, Yingjie
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927701/
https://ncbi.nlm.nih.gov/pubmed/31726940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2019.1688951
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