BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is often found in diseases, the underlying cellular mechanisms remain poorly defined. Here we show that the receptor BMP type 2 (...

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Publicat a:PLoS Biol
Autors principals: Hiepen, Christian, Jatzlau, Jerome, Hildebrandt, Susanne, Kampfrath, Branka, Goktas, Melis, Murgai, Arunima, Cuellar Camacho, Jose Luis, Haag, Rainer, Ruppert, Clemens, Sengle, Gerhard, Cavalcanti-Adam, Elisabetta Ada, Blank, Kerstin G., Knaus, Petra
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927666/
https://ncbi.nlm.nih.gov/pubmed/31826007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000557
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