BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Balanced transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP)-signaling is essential for tissue formation and homeostasis. While gain in TGFβ signaling is often found in diseases, the underlying cellular mechanisms remain poorly defined. Here we show that the receptor BMP type 2 (...

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Udgivet i:PLoS Biol
Main Authors: Hiepen, Christian, Jatzlau, Jerome, Hildebrandt, Susanne, Kampfrath, Branka, Goktas, Melis, Murgai, Arunima, Cuellar Camacho, Jose Luis, Haag, Rainer, Ruppert, Clemens, Sengle, Gerhard, Cavalcanti-Adam, Elisabetta Ada, Blank, Kerstin G., Knaus, Petra
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927666/
https://ncbi.nlm.nih.gov/pubmed/31826007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000557
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