Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo

A common pathological hallmark of amyotrophic lateral sclerosis (ALS) and the related neurodegenerative disorder frontotemporal dementia, is the cellular mislocalization of transactive response DNA-binding protein 43 kDa (TDP-43). Additionally, multiple mutations in the TARDBP gene (encoding TDP-43)...

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Publicado en:Hum Mol Genet
Autores principales: Williamson, Matthew G, Finelli, Mattéa J, Sleigh, James N, Reddington, Amy, Gordon, David, Talbot, Kevin, Davies, Kay E, Oliver, Peter L
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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General Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927465/
https://ncbi.nlm.nih.gov/pubmed/31642482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz190
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