Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and genetic reduction of SMN levels exacerbates the phen...

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Detalles Bibliográficos
Main Authors: Turner, Bradley J., Alfazema, Neza, Sheean, Rebecca K., Sleigh, James N., Davies, Kay E., Horne, Malcolm K., Talbot, Kevin
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2014
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919158/
https://ncbi.nlm.nih.gov/pubmed/24210254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2013.09.030
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