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Zebrafish survival motor neuron mutants exhibit presynaptic neuromuscular junction defects
Spinal muscular atrophy (SMA), a recessive genetic disease, affects lower motoneurons leading to denervation, atrophy, paralysis and in severe cases death. Reduced levels of survival motor neuron (SMN) protein cause SMA. As a first step towards generating a genetic model of SMA in zebrafish, we iden...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742401/ https://ncbi.nlm.nih.gov/pubmed/19592581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp310 |
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