Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy

Cardiac pathology is emerging as a prominent systemic feature of spinal muscular atrophy (SMA), but little is known about the underlying molecular pathways. Using quantitative proteomics analysis, we demonstrate widespread molecular defects in heart tissue from the Taiwanese mouse model of severe SM...

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Publicat a:Hum Mol Genet
Autors principals: Šoltić, Darija, Shorrock, Hannah K, Allardyce, Hazel, Wilson, Emma L, Holt, Ian, Synowsky, Silvia A, Shirran, Sally L, Parson, Simon H, Gillingwater, Thomas H, Fuller, Heidi R
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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General Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927462/
https://ncbi.nlm.nih.gov/pubmed/31397869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz195
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