Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-dependent pathways regulate neuromuscular pathology in S...

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Библиографические подробности
Главные авторы: Wishart, Thomas M., Mutsaers, Chantal A., Riessland, Markus, Reimer, Michell M., Hunter, Gillian, Hannam, Marie L., Eaton, Samantha L., Fuller, Heidi R., Roche, Sarah L., Somers, Eilidh, Morse, Robert, Young, Philip J., Lamont, Douglas J., Hammerschmidt, Matthias, Joshi, Anagha, Hohenstein, Peter, Morris, Glenn E., Parson, Simon H., Skehel, Paul A., Becker, Thomas, Robinson, Iain M., Becker, Catherina G., Wirth, Brunhilde, Gillingwater, Thomas H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2014
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973095/
https://ncbi.nlm.nih.gov/pubmed/24590288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71318
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