Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy

The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is unclear how reduced SMN promotes SMA development. Here, we determined that ubiquitin-dependent pathways regulate neuromuscular pathology in S...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wishart, Thomas M., Mutsaers, Chantal A., Riessland, Markus, Reimer, Michell M., Hunter, Gillian, Hannam, Marie L., Eaton, Samantha L., Fuller, Heidi R., Roche, Sarah L., Somers, Eilidh, Morse, Robert, Young, Philip J., Lamont, Douglas J., Hammerschmidt, Matthias, Joshi, Anagha, Hohenstein, Peter, Morris, Glenn E., Parson, Simon H., Skehel, Paul A., Becker, Thomas, Robinson, Iain M., Becker, Catherina G., Wirth, Brunhilde, Gillingwater, Thomas H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973095/
https://ncbi.nlm.nih.gov/pubmed/24590288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71318
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados