Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy

BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing the need for robust and sensitive clinical tri...

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Detalhes bibliográficos
Main Authors: Mutsaers, Chantal A, Lamont, Douglas J, Hunter, Gillian, Wishart, Thomas M, Gillingwater, Thomas H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979019/
https://ncbi.nlm.nih.gov/pubmed/24134804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm498
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