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(19)F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode
The final step in the biosynthesis of l-carnitine in humans is catalysed by the 2-oxoglutarate and ferrous iron dependent oxygenase, γ-butyrobetaine hydroxylase (BBOX). (1)H and (19)F NMR studies inform on the BBOX mechanism including by providing evidence for cooperativity between monomers in subst...
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| Publicado no: | Chem Commun (Camb) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6927413/ https://ncbi.nlm.nih.gov/pubmed/31702759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc06466d |
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