Cation–π Interactions Contribute to Substrate Recognition in γ‐Butyrobetaine Hydroxylase Catalysis

γ‐Butyrobetaine hydroxylase (BBOX) is a non‐heme Fe(II)‐ and 2‐oxoglutarate‐dependent oxygenase that catalyzes the stereoselective hydroxylation of an unactivated C−H bond of γ‐butyrobetaine (γBB) in the final step of carnitine biosynthesis. BBOX contains an aromatic cage for the recognition of the...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Kamps, Jos J. A. G., Khan, Amjad, Choi, Hwanho, Lesniak, Robert K., Brem, Jürgen, Rydzik, Anna M., McDonough, Michael A., Schofield, Christopher J., Claridge, Timothy D. W., Mecinović, Jasmin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736438/
https://ncbi.nlm.nih.gov/pubmed/26660433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201503761
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