Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH

BACKGROUND: Non-alcoholic steatohepatitis (NASH) is a progressive liver disease characterized by hepatic steatosis, lobular inflammation and fibrosis. Acetyl-CoA carboxylase (ACC) isoform 1 and 2 involved in de novo lipogenesis (DNL) and fatty acid oxidation have been identified as a therapeutic tar...

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Detalhes bibliográficos
Publicado no:PeerJ
Main Authors: Lu, Ying, Su, Xiaolan, Zhao, Manyu, Zhang, Qianru, Liu, Chuang, Lai, Qinhuai, Wu, Sijia, Fang, Aiping, Yang, Jinliang, Chen, Xiaoxin, Yao, Yuqin
Formato: Artigo
Idioma:Inglês
Publicado em: PeerJ Inc. 2019
Assuntos:
Bioinformatics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927352/
https://ncbi.nlm.nih.gov/pubmed/31879571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.8115
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