Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems

BACKGROUND & AIMS: Disordered metabolism, steatosis, hepatic inflammation, and fibrosis contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl-CoA carboxylase (ACC) catalyzes the first committed step in de novo lipogenesis (DNL) and modulates mitochondrial fatty acid oxida...

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Publicado en:Cell Mol Gastroenterol Hepatol
Main Authors: Ross, Trenton T., Crowley, Collin, Kelly, Kenneth L., Rinaldi, Anthony, Beebe, David A., Lech, Matthew P., Martinez, Robert V., Carvajal-Gonzalez, Santos, Boucher, Magalie, Hirenallur-Shanthappa, Dinesh, Morin, Jeffrey, Opsahl, Alan C., Vargas, Sarah R., Bence, Kendra K., Pfefferkorn, Jeffrey A., Esler, William P.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7509217/
https://ncbi.nlm.nih.gov/pubmed/32526482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.06.001
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