The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model

Peroxisome proliferator-activated receptor α/δ (PPAR α/δ), regulating glucolipid metabolism and immune inflammation, has been identified as an effective therapeutic target in non-alcoholic steatohepatitis (NASH). Dual PPAR α/δ agonist, such as GFT505 (also known as elafibranor), demonstrated potenti...

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Pubblicato in:PLoS One
Autori principali: Liu, Linfu, Liu, Chuang, Zhao, Manyu, Zhang, Qianru, Lu, Ying, Liu, Ping, Yang, Hua, Yang, Jinliang, Chen, Xiaoxin, Yao, Yuqin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7743980/
https://ncbi.nlm.nih.gov/pubmed/33326461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0243911
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