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Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalizati...
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| Publicado no: | Genome Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6927181/ https://ncbi.nlm.nih.gov/pubmed/31870423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1874-1 |
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