Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression

BACKGROUND: Deep sequencing of transposon mutant libraries (or TnSeq) is a powerful method for probing essentiality of genomic loci under different environmental conditions. Various analytical methods have been described for identifying conditionally essential genes whose tolerance for insertions va...

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Bibliographic Details
Published in:BMC Bioinformatics
Main Authors: Subramaniyam, Siddharth, DeJesus, Michael A., Zaveri, Anisha, Smith, Clare M., Baker, Richard E., Ehrt, Sabine, Schnappinger, Dirk, Sassetti, Christopher M., Ioerger, Thomas R.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6873424/
https://ncbi.nlm.nih.gov/pubmed/31752678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3156-z
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