Structure Guided Design, Synthesis and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization

A promising design paradigm for small-molecule inhibitors of tubulin polymerization that bind to the colchicine site draws structural inspiration from the natural products colchicine and combretastatin A-4 (CA4). Our previous studies with benzocycloalkenyl and heteroaromatic ring systems yielded pro...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Niu, Haichan, Strecker, Tracy E., Gerberich, Jeni L., Campbell, James W., Saha, Debabrata, Mondal, Deboprosad, Hamel, Ernest, Chaplin, David J., Mason, Ralph P., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925959/
https://ncbi.nlm.nih.gov/pubmed/31059248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00551
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