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Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates
The Phosphoprotein Phosphatase Calcineurin (CN, PP2B, PP3) recognizes and binds to two short linear motifs (SLiMs), PxIxIT and LxVP, in its regulators and substrates. These interactions enable CN function in many key biological processes. The identification of SLiMs is difficult because of their sho...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6925343/ https://ncbi.nlm.nih.gov/pubmed/31633908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00606 |
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