Dusp8 affects hippocampal size and behavior in mice and humans

Dual-specificity phosphatase 8 (Dusp8) acts as physiological inhibitor for the MAPKs Jnk, Erk and p38 which are involved in regulating multiple CNS processes. While Dusp8 expression levels are high in limbic areas such as the hippocampus, the functional role of Dusp8 in hippocampus morphology, MAPK-...

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Publicado en:Sci Rep
Main Authors: Baumann, Peter, Schriever, Sonja C., Kullmann, Stephanie, Zimprich, Annemarie, Feuchtinger, Annette, Amarie, Oana, Peter, Andreas, Walch, Axel, Gailus-Durner, Valerie, Fuchs, Helmut, Hrabě de Angelis, Martin, Wurst, Wolfgang, Tschöp, Matthias H., Heni, Martin, Hölter, Sabine M., Pfluger, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925303/
https://ncbi.nlm.nih.gov/pubmed/31862894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55527-7
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