Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity

Recent genome-wide association studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases, as a type 2 diabetes (T2D) risk gene. Here, we reveal that Dusp8 is a gatekeeper in the hypothalamic control of glucose homeostasis in mice and humans....

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Vydáno v:J Clin Invest
Hlavní autoři: Schriever, Sonja C., Kabra, Dhiraj G., Pfuhlmann, Katrin, Baumann, Peter, Baumgart, Emily V., Nagler, Joachim, Seebacher, Fabian, Harrison, Luke, Irmler, Martin, Kullmann, Stephanie, Corrêa-da-Silva, Felipe, Giesert, Florian, Jain, Ruchi, Schug, Hannah, Castel, Julien, Martinez, Sarah, Wu, Moya, Häring, Hans-Ulrich, de Angelis, Martin Hrabe, Beckers, Johannes, Müller, Timo D., Stemmer, Kerstin, Wurst, Wolfgang, Rozman, Jan, Nogueiras, Ruben, De Angelis, Meri, Molkentin, Jeffery D., Krahmer, Natalie, Yi, Chun-Xia, Schmidt, Mathias V., Luquet, Serge, Heni, Martin, Tschöp, Matthias H., Pfluger, Paul T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598066/
https://ncbi.nlm.nih.gov/pubmed/32780722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136363
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