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Polyanions provide selective control of APC/C interactions with the activator subunit

Transient interactions between the anaphase-promoting complex/cyclosome (APC/C) and its activator subunit Cdc20 or Cdh1 generate oscillations in ubiquitylation activity necessary to maintain the order of cell cycle events. Activator binds the APC/C with high affinity and exhibits negligible dissocia...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Mizrak, Arda, Morgan, David O.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925294/
https://ncbi.nlm.nih.gov/pubmed/31862931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13864-1
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