Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents

In present investigation, an attempt was undertaken to modify the C-9 position of noscapine (Nos), an opium alkaloid to yield 9 -hydroxy methyl and 9 -carbaldehyde oxime analogues for augmenting anticancer potential. The synthesis of 9-hydroxy methyl analogue of Nos was carried out by Blanc reaction...

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Vydáno v:Sci Rep
Hlavní autoři: Tomar, Vartika, Kumar, Neeraj, Tomar, Ravi, Sood, Damini, Dhiman, Neerupma, Dass, Sujata K., Prakash, Satya, Madan, Jitender, Chandra, Ramesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925231/
https://ncbi.nlm.nih.gov/pubmed/31862933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55839-8
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