Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy

Tumor-associated macrophages (TAMs) are often abundant in solid cancers, assuming an immunosuppressive (M2-like) phenotype which supports tumor growth and immune escape. Recent methods have focused on identification of means (e.g., drugs, nanomaterials) that polarize TAMs to a tumor suppressive (M1-...

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Udgivet i:Theranostics
Main Authors: Rodell, Christopher B., Ahmed, Maaz S., Garris, Christopher S., Pittet, Mikael J., Weissleder, Ralph
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924259/
https://ncbi.nlm.nih.gov/pubmed/31879528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35434
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