Integrative Development of a TLR8 Agonist for Ovarian Cancer Chemo-immunotherapy

BACKGROUND: Immunotherapy is an emerging paradigm for the treatment of cancer, but the potential efficacy of many drugs cannot be sufficiently tested in the mouse. We sought to develop a rational combination of motolimod—a novel Toll-like receptor 8 (TLR8) agonist that stimulates robust innate immun...

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Publicat a:Clin Cancer Res
Autors principals: Monk, Bradley J., Facciabene, Andrea, Brady, William E., Aghajanian, Carol A., Fracasso, Paula M., Walker, Joan L., Lankes, Heather A., Manjarrez, Kristi L., Danet-Desnoyers, Gwenn-äel H., Bell-McGuinn, Katherine M., McCourt, Carolyn K., Malykhin, Alexander, Hershberg, Robert M., Coukos, George
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437973/
https://ncbi.nlm.nih.gov/pubmed/27702821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1453
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