Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice

BACKGROUND: Alzheimer’s disease (AD) is a fatal neurodegenerative disease. APOE4 is the greatest genetic risk factor for AD, increasing risk up to 15-fold compared to the common APOE3. Importantly, female (♀) APOE4 carriers have a greater risk for developing AD and an increased rate of cognitive dec...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Maldonado Weng, Juan, Parikh, Ishita, Naqib, Ankur, York, Jason, Green, Stefan J., Estus, Steven, LaDu, Mary Jo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923910/
https://ncbi.nlm.nih.gov/pubmed/31861986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0352-2
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