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Dynamic CD138 surface expression regulates switch between myeloma growth and dissemination

The canonical plasma cell marker CD138 (syndecan-1) is highly expressed on the myeloma cell surface, but its functional role in vivo is unclear, as well as the ontogeny of CD138-high and CD138-negative (neg) myeloma cells. In this study we used an in vivo murine Vk*MYC myeloma model where CD138 is h...

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Détails bibliographiques
Publié dans:Leukemia
Auteurs principaux: Akhmetzyanova, Ilseyar, McCarron, Mark J., Parekh, Samir, Chesi, Marta, Bergsagel, P. Leif, Fooksman, David R.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923614/
https://ncbi.nlm.nih.gov/pubmed/31439945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-019-0519-4
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