CD138 mediates selection of mature plasma cells by regulating their survival

Antibody secreting cells (ASCs) are critical effector cells and long-lived sentinels for immune memory. ASCs are highly dependent on exogenous soluble factors such as interleukin-6 (IL-6) and APRIL, to prevent their cell death. We have found that the canonical surface marker of ASCs, CD138 (syndecan...

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Publicado en:Blood
Autores principales: McCarron, Mark J., Park, Pyong Woo, Fooksman, David R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2017
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437827/
https://ncbi.nlm.nih.gov/pubmed/28381397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-01-761643
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