Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes

Neuronal types in the central nervous system differ dramatically in their resilience to injury or insults. Here we studied the selective resilience of mouse retinal ganglion cells (RGCs) following optic nerve crush (ONC), which severs their axons and leads to death of ~80% of RGCs within 2 weeks. To...

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Publicado no:Neuron
Main Authors: Tran, Nicholas M., Shekhar, Karthik, Whitney, Irene E., Jacobi, Anne, Benhar, Inbal, Hong, Guosong, Yan, Wenjun, Adiconis, Xian, Arnold, McKinzie E., Lee, Jung Min, Levin, Joshua Z., Lin, Dingchang, Wang, Chen, Lieber, Charles M., Regev, Aviv, He, Zhigang, Sanes, Joshua R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923571/
https://ncbi.nlm.nih.gov/pubmed/31784286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.11.006
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