Guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen/glucose deprivation in cortical astrocyte cultures: involvement of A(1) and A(2A) adenosine receptors and PI3K, MEK, and PKC pathways

Glial cells are involved in multiple cerebral functions that profoundly influence brain tissue viability during ischemia, and astrocytes are the main source of extracellular purines as adenosine and guanosine. The endogenous guanine-based nucleoside guanosine is a neuromodulator implicated in import...

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Detaylı Bibliyografya
Yayımlandı:Purinergic Signal
Asıl Yazarlar: Dal-Cim, Tharine, Poluceno, Gabriela G., Lanznaster, Débora, de Oliveira, Karen A., Nedel, Claudia B., Tasca, Carla I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Netherlands 2019
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923312/
https://ncbi.nlm.nih.gov/pubmed/31520282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-019-09679-w
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