Automated minute scale RNA-seq of pluripotent stem cell differentiation reveals early divergence of human and mouse gene expression kinetics

Pluripotent stem cells retain the developmental timing of their species of origin in vitro, an observation that suggests the existence of a cell-intrinsic developmental clock, yet the nature and machinery of the clock remain a mystery. We hypothesize that one possible component may lie in species-sp...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Barry, Christopher, Schmitz, Matthew T., Argus, Cara, Bolin, Jennifer M., Probasco, Mitchell D., Leng, Ning, Duffin, Bret M., Steill, John, Swanson, Scott, McIntosh, Brian E., Stewart, Ron, Kendziorski, Christina, Thomson, James A., Bacher, Rhonda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922475/
https://ncbi.nlm.nih.gov/pubmed/31815944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007543
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