Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Faithful replication and repair of DNA lesions ensure genome maintenance. During replication in eukaryotic cells, DNA is unwound by the CMG helicase complex, which is composed of three major components: the Cdc45 protein, Mcm2-7, and the GINS complex. The CMG in complex with DNA polymerase epsilon (...

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Udgivet i:PLoS Genet
Main Authors: Jedrychowska, Malgorzata, Denkiewicz-Kruk, Milena, Alabrudzinska, Malgorzata, Skoneczna, Adrianna, Jonczyk, Piotr, Dmowski, Michal, Fijalkowska, Iwona J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922473/
https://ncbi.nlm.nih.gov/pubmed/31815930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008494
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