Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Faithful replication and repair of DNA lesions ensure genome maintenance. During replication in eukaryotic cells, DNA is unwound by the CMG helicase complex, which is composed of three major components: the Cdc45 protein, Mcm2-7, and the GINS complex. The CMG in complex with DNA polymerase epsilon (...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Jedrychowska, Malgorzata, Denkiewicz-Kruk, Milena, Alabrudzinska, Malgorzata, Skoneczna, Adrianna, Jonczyk, Piotr, Dmowski, Michal, Fijalkowska, Iwona J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922473/
https://ncbi.nlm.nih.gov/pubmed/31815930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008494
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