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Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint

To preserve genome integrity, the S-phase checkpoint senses damaged DNA or nucleotide depletion and when necessary, arrests replication progression and delays cell division. Previous studies, based on two pol2 mutants have suggested the involvement of DNA polymerase epsilon (Pol ε) in sensing DNA re...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Dmowski, Michał, Rudzka, Justyna, Campbell, Judith L., Jonczyk, Piotr, Fijałkowska, Iwona J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291541/
https://ncbi.nlm.nih.gov/pubmed/28107343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006572
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