Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation

Antibiotic-resistant Klebsiella pneumoniae isolates constitute a great clinical challenge. One important resistance mechanism in K. pneumoniae is the metallo-β-lactamases (MBLs), which require zinc for their function. Thus, zinc chelation could be a strategy to resensitize K. pneumoniae to β-lactams...

Full description

Saved in:
Bibliographic Details
Published in:Infect Immun
Main Authors: Karadottir, Harpa, Coorens, Maarten, Liu, Zhihai, Wang, Yang, Agerberth, Birgitta, Giske, Christian G., Bergman, Peter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Bacterial Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921649/
https://ncbi.nlm.nih.gov/pubmed/31611270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00756-19
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items