Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans

BACKGROUND: Chagas disease (CD) is a tropical parasitic disease. Although the number of people infected is very high, the only drugs available to treat CD, nifurtimox (Nfx) and benznidazole, are highly toxic, particularly in the chronic stage of the disease. Coumarins are a large class of compounds...

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Bibliografske podrobnosti
izdano v:BMC Pharmacol Toxicol
Main Authors: Soares, Fabiana Gomes Nascimento, Göethel, Gabriela, Kagami, Luciano Porto, das Neves, Gustavo Machado, Sauer, Elisa, Birriel, Estefania, Varela, Javier, Gonçalves, Itamar Luís, Von Poser, Gilsane, González, Mercedes, Kawano, Daniel Fábio, Paula, Fávero Reisdorfer, de Melo, Eduardo Borges, Garcia, Solange Cristina, Cerecetto, Hugo, Eifler-Lima, Vera Lucia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921407/
https://ncbi.nlm.nih.gov/pubmed/31852548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-019-0357-z
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