CRF(1) Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms

In the present study, we determined the cellular regulators of ERK1/2 and Akt signaling pathways in response to human CRF(1) receptor (CRF(1)R) activation in transfected COS-7 cells. We found that Pertussis Toxin (PTX) treatment or sequestering Gβγ reduced CRF(1)R-mediated activation of ERK1/2, sugg...

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Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Parra-Mercado, G. Karina, Fuentes-Gonzalez, Alma M., Hernandez-Aranda, Judith, Diaz-Coranguez, Monica, Dautzenberg, Frank M., Catt, Kevin J., Hauger, Richard L., Olivares-Reyes, J. Alberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921279/
https://ncbi.nlm.nih.gov/pubmed/31920979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00869
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