Desensitization of Human CRF(2(a)) Receptor Signaling Governed by Agonist Potency and βArrestin2 Recruitment

The primary goal was to determine agonist-specific regulation of CRF(2(a)) receptor function. Exposure of human retinoblastoma Y79 cells to selective (UCN2, UCN3 or stresscopins) and nonselective (UCN1 or sauvagine) agonists prominently desensitized CRF(2(a)) receptors in a rapid, concentration-depe...

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Bibliographic Details
Main Authors: Hauger, Richard L., Olivares-Reyes, J. Alberto, Braun, Sandra, Hernandez-Aranda, Judith, Hudson, Christine C., Gutknecht, Eric, Dautzenberg, Frank M., Oakley, Robert H.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924877/
https://ncbi.nlm.nih.gov/pubmed/23820308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.regpep.2013.06.009
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