Pharmacological blockade of PCAF ameliorates osteoarthritis development via dual inhibition of TNF-α-driven inflammation and ER stress

BACKGROUND: Epigenetic mechanisms have been reported to play key roles in osteoarthritis (OA) development. P300/CBP-associated factor (PCAF) is a member of the histone acetyltransferases, which exhibits a strong relationship with endoplasmic reticulum (ER) stress and transcription factor nuclear fac...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Chen, Deheng, Lu, Di, Liu, Haixiao, Xue, Enxing, Zhang, Yu, Shang, Ping, Pan, Xiaoyun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921217/
https://ncbi.nlm.nih.gov/pubmed/31735552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.054
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