Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

Oxidative stress-related apoptosis and autophagy play crucial roles in the development of osteoarthritis (OA), a progressive cartilage degenerative disease with multifactorial etiologies. Here, we determined autophagic flux changes and apoptosis in human OA and tert-Butyl hydroperoxide (TBHP)-treate...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Tang, Qian, Zheng, Gang, Feng, Zhenhua, Chen, Yu, Lou, Yiting, Wang, Chenggui, Zhang, Xiaolei, Zhang, Yu, Xu, Huazi, Shang, Ping, Liu, Haixiao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680575/
https://ncbi.nlm.nih.gov/pubmed/28981117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.453
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