CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils

Immunomodulatory peptide cathelicidin/LL-37 induces human monocyte differentiation into a novel bone repair cell, the monoosteophil. We now demonstrate that LL-37 is endocytosed by monocytes over a period of 6 days producing large (10 × 2 μm), specialized LL-37 and integrin α3 positive vesicles. CXC...

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Vydáno v:Bone Rep
Hlavní autoři: Zhang, Zhifang, Le, Keith, La Placa, Deirdre, Armstrong, Brian, Miller, Marcia M., Shively, John E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921147/
https://ncbi.nlm.nih.gov/pubmed/31886324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2019.100237
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