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EVIDENCE THAT CATHELICIDIN PEPTIDE LL-37 MAY ACT AS A FUNCTIONAL LIGAND FOR CXCR2 ON HUMAN NEUTROPHILS
LL-37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL-37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down-regulated by LL-37. LL-37 functions similarly to CXCR2 specific chemokines CXCL1 and CXCL7...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076219/ https://ncbi.nlm.nih.gov/pubmed/19750480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939496 |
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