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EVIDENCE THAT CATHELICIDIN PEPTIDE LL-37 MAY ACT AS A FUNCTIONAL LIGAND FOR CXCR2 ON HUMAN NEUTROPHILS

LL-37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL-37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down-regulated by LL-37. LL-37 functions similarly to CXCR2 specific chemokines CXCL1 and CXCL7...

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Bibliografiske detaljer
Main Authors: Zhang, Zhifang, Cherryholmes, Gregory, Chang, Frances, Rose, David M., Schraufstatter, Ingrid, Shively, John E.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076219/
https://ncbi.nlm.nih.gov/pubmed/19750480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939496
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