Conjugation of Amisulpride, an Anti-Psychotic Agent, with 5-Aminosalicylic Acid via an Azo Bond Yields an Orally Active Mutual Prodrug against Rat Colitis

Amisulpride (ASP), an anti-psychotic agent, is a pharmacologically equivalent to sulpiride (SP). Because SP demonstrates anti-ulcer and anti-colitic activities, ASP with an aniline moiety was azo-coupled to salicylic acid to generate 5-(aminoethanoylsulfamoyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-me...

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Detaylı Bibliyografya
Yayımlandı:Pharmaceutics
Asıl Yazarlar: Kim, Wooseong, Kim, Dayoon, Jeong, Seongkeun, Ju, Sanghyun, Lee, Hanju, Kim, Soojin, Yoo, Jin-Wook, Yoon, In-Soo, Jung, Yunjin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920822/
https://ncbi.nlm.nih.gov/pubmed/31703411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11110585
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