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Dynamic DNA Energy Landscapes and Substrate Complexity in Triplet Repeat Expansion and DNA Repair

DNA repeat domains implicated in DNA expansion diseases exhibit complex conformational and energy landscapes that impact biological outcomes. These landscapes include ensembles of entropically driven positional interchanges between isoenergetic, isomeric looped states referred to as rollamers. Here,...

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發表在:Biomolecules
Main Authors: Völker, Jens, Plum, G. Eric, Gindikin, Vera, Breslauer, Kenneth J.
格式: Artigo
語言:Inglês
出版: MDPI 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920812/
https://ncbi.nlm.nih.gov/pubmed/31698848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9110709
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