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Energy Landscapes of Dynamic Ensembles of Rolling Triplet Repeat Bulge Loops: Implications for DNA Expansion Associated with Disease States

[Image: see text] DNA repeat domains can form ensembles of canonical and noncanonical states, including stable and metastable DNA secondary structures. Such sequence-induced structural diversity creates complex conformational landscapes for DNA processing pathways, including those triplet expansion...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Völker, Jens, Gindikin, Vera, Klump, Horst H., Plum, G. Eric, Breslauer, Kenneth J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2012
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318849/
https://ncbi.nlm.nih.gov/pubmed/22397401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3010896
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