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Energetic Coupling Between Clustered Lesions Modulated by Intervening Triplet Repeat Bulge Loops: Allosteric Implications for DNA Repair and Triplet Repeat Expansion

Clusters of closely spaced oxidative DNA lesions present challenges to the cellular repair machinery. When located in opposing strands, base excision repair (BER) of such lesions can lead to double strand DNA breaks (DSB). Activation of BER and DSB repair pathways has been implicated in inducing enh...

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Detalhes bibliográficos
Main Authors: Völker, Jens, Plum, G.Eric, Klump, Horst H., Breslauer, Kenneth J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902826/
https://ncbi.nlm.nih.gov/pubmed/19890964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21343
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