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Energetic Coupling Between Clustered Lesions Modulated by Intervening Triplet Repeat Bulge Loops: Allosteric Implications for DNA Repair and Triplet Repeat Expansion
Clusters of closely spaced oxidative DNA lesions present challenges to the cellular repair machinery. When located in opposing strands, base excision repair (BER) of such lesions can lead to double strand DNA breaks (DSB). Activation of BER and DSB repair pathways has been implicated in inducing enh...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902826/ https://ncbi.nlm.nih.gov/pubmed/19890964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21343 |
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