A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

Age-progressive neurodegenerative pathologies, including Alzheimer’s disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Kakraba, Samuel, Ayyadevara, Srinivas, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Ganne, Akshatha, Liu, Ling, Alla, Ramani, Bommagani, Shoban Babu, Barger, Steven W., Griffin, W. Sue T., Crooks, Peter A., Shmookler Reis, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920216/
https://ncbi.nlm.nih.gov/pubmed/31920540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00310
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